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Infection and Immunity, April 2004, p. 2408-2411, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2408-2411.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Porphyromonas gingivalis-Specific Immunoglobulin G Prevents P. gingivalis-Elicited Oral Bone Loss in a Murine Model

Frank C. Gibson III,1 Dario A. Gonzalez,2 Jodie Wong,2 and Caroline Attardo Genco1,2*

Department of Medicine, Section of Infectious Diseases,1 Department of Oral Biology and Periodontology, Goldman School of Dental Medicine, Boston University Medical Center, Boston, Massachusetts 021182

Received 1 August 2003/ Returned for modification 1 October 2003/ Accepted 2 January 2004

Active immunization with Porphyromonas gingivalis whole-cell preparations has been shown to prevent P. gingivalis infection and oral bone loss. Employing passive antibody transfer and opsonization, we demonstrate with this study that immunization-elicited P. gingivalis-specific immunoglobulin G facilitates clearance of P. gingivalis in a subcutaneous chamber model and prevents P. gingivalis-elicited oral bone loss.

* Corresponding author. Mailing address: Department of Medicine, Boston Medical Center, 650 Albany St., Boston, MA 02118. Phone: (617) 414-5305. Fax: (617) 414-5280. E-mail: caroline.genco{at}bmc.org.

Editor: A. D. O'Brien

Infection and Immunity, April 2004, p. 2408-2411, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2408-2411.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Miyachi, K., Ishihara, K., Kimizuka, R., Okuda, K. (2007). Arg-gingipain A DNA Vaccine Prevents Alveolar Bone Loss in Mice. JDR 86: 446-450 [Abstract] [Full Text]  
  • Teng, Y.-T.A. (2006). Protective and Destructive Immunity in the Periodontium: Part 1--Innate and Humoral Immunity and the Periodontium. JDR 85: 198-208 [Abstract] [Full Text]  
  • Teng, Y.-T.A. (2006). Protective and Destructive Immunity in the Periodontium: Part 2--T-cell-mediated Immunity in the Periodontium. JDR 85: 209-219 [Abstract] [Full Text]  


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