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Infection and Immunity, April 2004, p. 2429-2433, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2429-2433.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Different Responses of Macrophages to Smooth and Rough Brucella spp.: Relationship to Virulence

Unidad de Sanidad Animal, Servicio de Investigación Agroalimentaria, Diputación General de Aragón, 50080 Zaragoza, Spain,¹ INSERM U431, Université de Montpellier II, 34095 Montpellier, France²

Received 3 November 2003/ Returned for modification 14 November 2003/ Accepted 11 December 2003

By comparing smooth wild-type Brucella strains to their rough mutants, we show that the lipopolysaccharide (LPS) O side chain of pathogenic Brucella has a dramatic impact on macrophage activation. It favors the development of virulent Brucella by preventing the synthesis of immune mediators, important for host defense. We conclude that this O chain property is firmly linked to Brucella virulence.

Editor: D. L. Burns

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