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Infection and Immunity, April 2004, p. 2429-2433, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2429-2433.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Different Responses of Macrophages to Smooth and Rough Brucella spp.: Relationship to Virulence

María P. Jiménez de Bagüés,1* Annie Terraza,2 Antoine Gross,2 and Jacques Dornand2

Unidad de Sanidad Animal, Servicio de Investigación Agroalimentaria, Diputación General de Aragón, 50080 Zaragoza, Spain,1 INSERM U431, Université de Montpellier II, 34095 Montpellier, France2

Received 3 November 2003/ Returned for modification 14 November 2003/ Accepted 11 December 2003

By comparing smooth wild-type Brucella strains to their rough mutants, we show that the lipopolysaccharide (LPS) O side chain of pathogenic Brucella has a dramatic impact on macrophage activation. It favors the development of virulent Brucella by preventing the synthesis of immune mediators, important for host defense. We conclude that this O chain property is firmly linked to Brucella virulence.

* Corresponding author. Mailing address: Unidad de Sanidad Animal, Servicio de Investigación Agroalimentaria, Diputación General de Aragón, Ap. 727, 50080 Zaragoza, Spain. Phone: 34-976-716-457. Fax: 34-976-716-335. E-mail: mpjimenezdebagues{at}aragob.es.

Editor: D. L. Burns

Infection and Immunity, April 2004, p. 2429-2433, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2429-2433.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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