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Infection and Immunity, April 2004, p. 2438-2441, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2438-2441.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Yersinia pseudotuberculosis Anti-Inflammatory Components Reduce Trinitrobenzene Sulfonic Acid-Induced Colitis in the Mouse

Michael Marceau,1,{dagger} Laurent Dubuquoy,2,{dagger},{ddagger} Christel Caucheteux-Rousseaux,2 Benoit Foligne,3 Pierre Desreumaux,2 and Michel Simonet1*

E0364 INSERM—Université de Lille II, Faculté de Médecine and Institut de Biologie de Lille,1 Equipe INSERM 0114, Centre Hospitalier Régional et Universitaire de Lille,2 Laboratoire de Bactériologie des Ecosystèmes, Institut Pasteur de Lille, Lille, France3

Received 4 September 2003/ Returned for modification 28 October 2003/ Accepted 18 December 2003

Rectal instillation of trinitrobenzene sulfonic acid (TNBS) induces acute colitis in the mouse. We tested the efficacy of Yersinia pseudotuberculosis anti-inflammatory components in preventing TNBS-triggered colitis. Animals were orally inoculated with virulence-attenuated Yersinia cells (a phoP mutant) prior to TNBS administration. Under these experimental conditions, colonic lesions and tumor necrosis factor alpha mRNA levels were significantly reduced.

* Corresponding author. Mailing address: Département de Pathogenèse des Maladies Infectieuses, Institut de Biologie de Lille, 1 rue du Professeur Calmette, F-59021 Lille Cedex, France. Phone: 33-3-20-87-11-78. Fax: 33-3-20-87-11-83. E-mail: michel.simonet{at}ibl.fr.

Editor: J. B. Bliska

{dagger} M.M. and L.D. contributed equally to this work.

{ddagger} Present address: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/Inserm/ULP, 67404 Illkirch, France.

Infection and Immunity, April 2004, p. 2438-2441, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2438-2441.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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