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Infection and Immunity, April 2004, p. 2442-2444, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2442-2444.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Adaptation of Diverse Lyme Disease Spirochetes in a Natural Rodent Reservoir Host

Dania Richter,1* Birte Klug,1 Andrew Spielman,2 and Franz-Rainer Matuschka1

Abteilung Parasitologie, Institut für Pathologie, Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin, 12249 Berlin, Germany,1 Laboratory of Public Health Entomology, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 021152

Received 14 October 2003/ Returned for modification 18 November 2003/ Accepted 13 January 2004

We compared the relative reservoir competence of European wood mice for two genospecies of Lyme disease spirochetes by analyzing susceptibility, intrinsic incubation period, and degree and duration of infectivity. Borrelia afzelii, specializing in particular reservoir hosts, is better adapted to those hosts than is the more generalist genospecies B. burgdorferi sensu stricto.

* Corresponding author. Mailing address: Abteilung Parasitologie, Institut für Pathologie, Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin, Malteserstraße 74-100, 12249 Berlin, Germany. Phone: 49-30-83-87-03-72. Fax: 49-30-77-62-085. E-mail: drichter{at}charite.de.

Editor: D. L. Burns

Infection and Immunity, April 2004, p. 2442-2444, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2442-2444.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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