This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kodama, C.
Right arrow Articles by Matsui, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kodama, C.
Right arrow Articles by Matsui, H.

 Previous Article  |  Next Article 

Infection and Immunity, April 2004, p. 2449-2451, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2449-2451.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Salmonella Flagellin Is Not a Dominant Protective Antigen in Oral Immunization with Attenuated Live Vaccine Strains

Chie Kodama1 and Hidenori Matsui1,2*

Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641,1 Center for Basic Research, The Kitasato Institute, Minato-ku, Tokyo 108-8642, Japan2

Received 16 September 2003/ Returned for modification 2 December 2003/ Accepted 5 January 2004

We found that oral immunization with flagellum-defective mutant strains of Salmonella enterica serovar Typhimurium with the ClpXP-deficient background protected mice against oral challenge with the virulent strain. These data indicate that Salmonella flagellin is not a dominant protective antigen in oral immunization with attenuated live vaccine strains.

* Corresponding author. Mailing address: Laboratory of Immunoregulation, Department of Infection Control and Immunology, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. Phone and fax: 81-3-5791-6267. E-mail: hmatsui{at}lisci.kitasato-u.ac.jp.

Editor: B. B. Finlay

Infection and Immunity, April 2004, p. 2449-2451, Vol. 72, No. 4
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.4.2449-2451.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Saha, S., Takeshita, F., Matsuda, T., Jounai, N., Kobiyama, K., Matsumoto, T., Sasaki, S., Yoshida, A., Xin, K.-Q., Klinman, D. M., Uematsu, S., Ishii, K. J., Akira, S., Okuda, K. (2007). Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine. J. Immunol. 179: 1147-1154 [Abstract] [Full Text]  
  • Adriaensen, C., De Greve, H., Tian, J. Q., De Craeye, S., Gubbels, E., Eeckhaut, V., Van Immerseel, F., Ducatelle, R., Kumar, M., Hernalsteens, J.-P. (2007). A Live Salmonella enterica Serovar Enteritidis Vaccine Allows Serological Differentiation between Vaccinated and Infected Animals. Infect. Immun. 75: 2461-2468 [Abstract] [Full Text]  
  • Cheminay, C., Mohlenbrink, A., Hensel, M. (2005). Intracellular Salmonella Inhibit Antigen Presentation by Dendritic Cells. J. Immunol. 174: 2892-2899 [Abstract] [Full Text]  
  • Rollenhagen, C., Sorensen, M., Rizos, K., Hurvitz, R., Bumann, D. (2004). Antigen selection based on expression levels during infection facilitates vaccine development for an intracellular pathogen. Proc. Natl. Acad. Sci. USA 101: 8739-8744 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»