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Infection and Immunity, May 2004, p. 2989-2994, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.2989-2994.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Tick Saliva Reduces Adherence and Area of Human Neutrophils

Ruth R. Montgomery,1* Denise Lusitani,1 Anne de Boisfleury Chevance,2 and Stephen E. Malawista1

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520,1 Centre d'Ecologie Cellulaire, Hôpital de la Salpétrière, Paris, France2

Received 12 December 2003/ Returned for modification 26 January 2004/ Accepted 9 February 2004

During natural infection with the agent of Lyme disease, Borrelia burgdorferi, spirochetes are delivered with vector saliva, which contains anti-inflammatory and antihemostatic activities. We show here that the saliva of ixodid ticks reduces polymorphonuclear leukocyte (PMN) adhesion via downregulation of ß2-integrins and decreases the efficiency of PMN in the uptake and killing of spirochetes. Inhibition of integrin adhesion and signaling reduces anti-inflammatory functions of PMN. These effects may favor the initial survival of spirochetes in vivo.

* Corresponding author. Mailing address: Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street/TAC S413, New Haven, CT 06520-8031. Phone: (203) 785-7039. Fax: (203) 785-7053. E-mail: ruth.montgomery{at}yale.edu.

Editor: D. L. Burns

Infection and Immunity, May 2004, p. 2989-2994, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.2989-2994.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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