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Infection and Immunity, May 2004, p. 3038-3041, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3038-3041.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Extra Cytoplasmic Function Sigma Factor {sigma}E Is Essential for Mycobacterium tuberculosis Virulence in Mice

Riccardo Manganelli,1 Lanfranco Fattorini,2 Dejiang Tan,2 Elisabetta Iona,2 Graziella Orefici,2 Giuseppe Altavilla,3 Paola Cusatelli,3 and Issar Smith4*

Department of Histology, Microbiology and Medical Biotechnologies,1 Institute of Pathologic Anatomy and Histology, University of Padua, Padua,2 Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome, Italy,2 TB Center, Public Health Research Institute, International Center for Public Health, Newark, New Jersey4

Received 11 August 2003/ Returned for modification 6 October 2003/ Accepted 5 February 2004

The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.

* Corresponding author. Mailing address: TB Center, Public Health Research Institute, 225 Warren St., Newark, NJ 07103-3535. Phone: (973) 854-3260. Fax: (973) 854-3261. E-mail: smitty{at}phri.org.

Editor: S. H. E. Kaufmann

Infection and Immunity, May 2004, p. 3038-3041, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3038-3041.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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