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Infection and Immunity, May 2004, p. 3042-3047, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3042-3047.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Presence of Pili on the Surface of Francisella tularensis

Center for Infectious Diseases, Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794-5120

Received 27 November 2003/ Returned for modification 17 December 2003/ Accepted 30 January 2004

Francisella tularensis is a highly infectious gram-negative bacterium with potential for use as a bioweapon. Analysis of the F. tularensis live vaccine strain (LVS) ultrastructure by electron microscopy revealed the presence of long, thin fibers, similar in appearance to type 4 pili. The highly virulent F. tularensis Schu S4 strain was found to contain type 4 pilus genes, and we confirmed that these genes are present and expressed in the LVS.

Editor: V. J. DiRita

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