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Infection and Immunity, May 2004, p. 3048-3053, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3048-3053.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Legionella pneumophila Replication Vacuole Formation Involves Rapid Recruitment of Proteins of the Early Secretory System

Isabelle Derré1 and Ralph R. Isberg1,2*

Department of Molecular Biology and Microbiology and,1 Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts 021112

Received 11 December 2003/ Returned for modification 7 January 2004/ Accepted 19 January 2004

Legionella pneumophila vacuole biogenesis was analyzed by using a cell-free system. We show that calnexin, Sec22b, and Rab1 are recruited to the vacuole very shortly after bacterial uptake, and we have identified Rab1 as a potential host factor involved in the endoplasmic reticulum recruitment process.

* Corresponding author. Mailing address: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Harrison Ave., Boston, MA 02111. Phone: (617) 636-3993. Fax: (617) 636-0337. E-mail: ralph.isberg{at}tufts.edu.

Editor: F. C. Fang

Infection and Immunity, May 2004, p. 3048-3053, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3048-3053.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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