This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Sanni, L. A. Articles by Langhorne, J. Search for Related Content PubMed PubMed Citation Articles by Sanni, L. A. Articles by Langhorne, J.

 Previous Article  |  Next Article 

Infection and Immunity, May 2004, p. 3054-3058, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3054-3058.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Cerebral Edema and Cerebral Hemorrhages in Interleukin-10-Deficient Mice Infected with Plasmodium chabaudi

Latifu A. Sanni, William Jarra, Ching Li, and Jean Langhorne^*

Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom

Received 19 December 2003/ Returned for modification 13 January 2004/ Accepted 27 January 2004

During a Plasmodium chabaudi infection in interleukin-10 (IL-10) knockout mice, there is greater parasite sequestration, more severe cerebral edema, and a high frequency of cerebral hemorrhage compared with infection of C57BL/6 mice. Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10^–/– mice.

Editor: W. A. Petri, Jr.

Present address: Department of Histopathology, The General Infirmary at Leeds, Leeds LS2 9JT, United Kingdom.

Present address: Kennedy Institute of Rheumatology Division, Imperial College London, Faculty of Medicine, London W6 8LH, United Kingdom.