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Infection and Immunity, May 2004, p. 3059-3062, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3059-3062.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Two Salmonella OmpC Kb-Restricted Epitopes for CD8+-T-Cell Recognition

Alberto Diaz-Quiñonez ,1,{dagger},§ Natalia Martin-Orozco,2,{ddagger},§ Armando Isibasi,2 and Vianney Ortiz-Navarrete1*

Departamento de Biomedicina Molecular, Centro de Investigación y Estudios Avanzados (CINVESTAV),, 07000 Mexico City,1 Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, CMN Siglo XXI, IMSS, Mexico City, Mexico2

Received 29 July 2003/ Returned for modification 4 November 2003/ Accepted 26 January 2004

We report the identification of two peptides from Salmonella OmpC porin that can bind to major histocompatibility complex class I Kb molecules and are targets of cytotoxic T lymphocytes from Salmonella-infected mice. These peptides are conserved in gram-negative bacterial porins and are the first Salmonella porin-specific epitopes described for possible CD8+-T-cell elimination of infected cells.

* Corresponding author. Mailing address: Av. Instituto Politécnico Nacional No. 2508, Col. San Pedro Zacatenco, 07360 Mexico City, Mexico. Phone: 52 (555) 5061-7134. Fax: 52 (555) 747-7134. E-mail: vortiz{at}mail.cinvestav.mx.

Editor: V. J. DiRita

{dagger} Present address: Dirección de Investigación en Inmunotecnología, Laboratorios Silanes SA de CV, 03100 Mexico City, Mexico.

§ A.D.-Q. and N.M.-O. contributed equally to this work.

{ddagger} Present address: Division of Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

Infection and Immunity, May 2004, p. 3059-3062, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3059-3062.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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