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Infection and Immunity, May 2004, p. 3063-3065, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3063-3065.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Proinflammatory Cytokine Expression in the Early Phase of Trypanosoma brucei rhodesiense Infection in Vervet Monkeys (Cercopithecus aethiops)

Naomi Maina,1 Joseph Maina Ngotho,1 Tom Were,1 John Kibuthu Thuita,1 David Mumo Mwangangi,1 John Maina Kagira,1 Joseph Mathu Ndung'u,1 and Jeremy Sternberg2*

Primate Division, Kenya Trypanosomiasis Research Institute, Kikuyu, Kenya,1 Department of Zoology, University of Aberdeen, Aberdeen AB29 2TZ, Scotland, United Kingdom2

Received 30 September 2003/ Returned for modification 8 October 2003/ Accepted 21 January 2004

A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-{alpha}) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

* Corresponding author. Mailing address: Department of Zoology, University of Aberdeen, Tillydrone Ave., Aberdeen AB29 2TZ, Scotland, United Kingdom. Phone: 44 1224 272272. Fax: 44 1224 272396. E-mail: j.sternberg{at}abdn.ac.uk.

Editor: W. A. Petri, Jr.

Infection and Immunity, May 2004, p. 3063-3065, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3063-3065.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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