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Infection and Immunity, May 2004, p. 3066-3068, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3066-3068.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Host Cell Chaperone Hsp90 Is Necessary for Cytotoxic Action of the Binary Iota-Like Toxins

Gerd Haug, Klaus Aktories, and Holger Barth*

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany

Received 24 October 2003/ Returned for modification 13 November 2003/ Accepted 29 November 2003

The heat shock protein Hsp90 is essential for uptake of the binary actin ADP-ribosylating toxins Clostridium perfringens iota-toxin and Clostridium difficile transferase into eukaryotic cells. Inhibition of Hsp90 by its specific inhibitor radicicol delayed intoxication of Vero cells by these toxins. A common Hsp90-dependent mechanism for their translocation is discussed.

* Corresponding author. Mailing address: Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Otto-Krayer-Haus, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, D-79104 Freiburg, Germany. Phone: 49-0761-2035308. Fax: 49-0761-2035311. E-mail: holger.barth{at}pharmakol.uni-freiburg.de.

Editor: D. L. Burns

Infection and Immunity, May 2004, p. 3066-3068, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3066-3068.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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