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Infection and Immunity, May 2004, p. 3069-3072, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3069-3072.2004

Macrophages Release Tumor Necrosis Factor Alpha and Interleukin-12 in Response to Intracellular Bacillus anthracis Spores

Alison K. Pickering and Tod J. Merkel*

Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892

Received 19 November 2003/ Returned for modification 13 January 2004/ Accepted 20 January 2004

Herein we report that infection of a murine macrophage cell line with Bacillus anthracis results in the production of tumor necrosis factor alpha and interleukin-12 (IL-12). When infected with B. anthracis spores in combination with lipopolysaccharide, macrophages release increased amounts of IL-12. We found no evidence of inhibition of cytokine responses in macrophages infected with B. anthracis spores.

* Corresponding author. Mailing address: Laboratory of Respiratory and Special Pathogens, DBPAP/CBER/FDA, Building 29, Room 418, 29 Lincoln Dr., Bethesda, MD 20892. Phone: (301) 496-5564. Fax: (301) 402-2776. E-mail: merkel{at}cber.fda.gov.

Editor: J. T. Barbieri

Infection and Immunity, May 2004, p. 3069-3072, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3069-3072.2004




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