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Infection and Immunity, May 2004, p. 3077-3080, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3077-3080.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Pneumococcal Surface Protein C Contributes to Sepsis Caused by Streptococcus pneumoniae in Mice

Francesco Iannelli,* Damiana Chiavolini, Susanna Ricci, Marco Rinaldo Oggioni, and Gianni Pozzi

Laboratory of Molecular Microbiology and Biotechnology, Department of Molecular Biology, University of Siena, 53100 Siena, Italy

Received 10 December 2003/ Returned for modification 28 January 2004/ Accepted 5 February 2004

The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal dose up to 250-fold higher than that for the wild type. Our findings indicate that PspC affords a decisive contribution to sepsis development.

* Corresponding author. Mailing address: LAMMB, Biologia Molecolare/Università, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy. Phone: 39-0577-233101. Fax: 39-0577-233334. E-mail: iannelli{at}unisi.it.

Editor: J. N. Weiser

Infection and Immunity, May 2004, p. 3077-3080, Vol. 72, No. 5
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.5.3077-3080.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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