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Infection and Immunity, June 2004, p. 3543-3548, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3543-3548.2004

CpG Oligodeoxynucleotides Improve the Survival of Pregnant and Fetal Mice following Listeria monocytogenes Infection

Shu-ichi Ito,1 Ken J. Ishii,1,3 Hidekazu Shirota,1 and Dennis M. Klinman1*

Section of Retroviral Immunology, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892,1 Department of Host Defense, Research Institute for Microbial Diseases, Osaka University,2 Solution-Oriented Research for Science and Technology, Japan Science and Technology Corp., Suita, Osaka 565-0871, Japan3

Received 13 November 2003/ Returned for modification 17 December 2003/ Accepted 23 February 2004

Listeria infection during pregnancy can cause the death of both mother and fetus. Previous studies established that immunostimulatory CpG oligodeoxynucleotides (ODN) increase the resistance of healthy adult mice to many infectious pathogens, including Listeria monocytogenes. This study examines whether the innate immune response elicited by CpG ODN can reduce the susceptibility of pregnant mice to lethal listeria challenge. The results indicate that CpG ODN treatment significantly improves maternal survival and reduces pathogen transmission to offspring. CpG ODN administered during pregnancy did not induce abortion, birth defects, or reduce the size or health of litters. These findings suggest that CpG ODN may provide a safe and effective means of improving the health of mothers and fetuses during pregnancy.

* Corresponding author. Mailing address: Bldg. 29A, Rm. 3D10, Division of Viral Products, CBER, FDA, 8800 Rockville Pike, Bethesda, MD 20892. Phone: (301) 827-1707. Fax: (301) 496-1810. E-mail: Klinman{at}cber.fda.gov.

Editor: F. C. Fang

Infection and Immunity, June 2004, p. 3543-3548, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3543-3548.2004




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