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Infection and Immunity, June 2004, p. 3638-3642, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3638-3642.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Delivery of the Immunosuppressive Antigen Salp15 to Antigen-Presenting Cells by Salmonella enterica Serovar Typhimurium aroA Mutants

Amir-Reza T. Motameni,{dagger} Ignacio J. Juncadella,{dagger} Shobana K. Ananthanarayanan, Michael N. Hedrick, Yvette Huet-Hudson, and Juan Anguita*

Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223

Received 17 November 2003/ Returned for modification 16 December 2003/ Accepted 3 March 2004

A Salmonella enterica serovar Typhimurium aroA-deficient delivery system was used to target the immunosuppressive protein Salp15 to antigen-presenting cells. In vitro and in vivo infections with Salp15-containing Salmonella resulted in an impaired CD4+-T-cell activation, suggesting that the protein was produced by antigen-presenting cells in a physiologically active form.

* Corresponding author. Mailing address: Department of Biology, University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte, NC 28223. Phone: (704) 687-3950. Fax: (704) 687-3128. E-mail: janguita{at}uncc.edu.

Editor: F. C. Fang

{dagger} A.-R.T.M. and I.J.J. contributed equally to this work.

Infection and Immunity, June 2004, p. 3638-3642, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3638-3642.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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