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Infection and Immunity, June 2004, p. 3643-3645, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3643-3645.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The {alpha}-Specific Cell Identity Factor Sxi1{alpha} Is Not Required for Virulence of Cryptococcus neoformans

Christina M. Hull,1,{dagger} Gary M. Cox,1,2 and Joseph Heitman1,2,3,4*

Departments of Molecular Genetics and Microbiology,1 Medicine,2 Pharmacology and Cancer Biology,3 Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 277104

Received 29 December 2003/ Returned for modification 27 January 2004/ Accepted 25 February 2004

Cryptococcus neoformans is a human fungal pathogen that has two mating types (a and {alpha}). Experiments have shown that in some backgrounds {alpha} strains are more virulent than a strains. Our studies reveal that the only known {alpha}-specific factor, SXI1{alpha}, is not necessary for virulence.

* Corresponding author. Mailing address: Department of Molecular Genetics and Microbiology, 322 CARL Building, Box 3546, Research Dr., Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-2824. Fax: (919) 684-5458. E-mail: heitm001{at}duke.edu.

Editor: T. R. Kozel

{dagger} Present address: Departments of Biomolecular Chemistry and Medical Microbiology and Immunology, University of Wisconsin, Madison, WI 53706.

Infection and Immunity, June 2004, p. 3643-3645, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3643-3645.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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