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Infection and Immunity, June 2004, p. 3646-3649, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3646-3649.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Helicobacter pylori Induces AGS Cell Motility and Elongation via Independent Signaling Pathways

Stefan Moese,1 Matthias Selbach,1 Terry Kwok,2 Volker Brinkmann,3 Wolfgang König,2 Thomas F. Meyer,1 and Steffen Backert2*

Department of Molecular Biology,1 Microscopy Unit, Max Planck Institute for Infection Biology, D-10117 Berlin,3 Department of Medical Microbiology, Otto von Guericke University, D-39120 Magdeburg, Germany2

Received 15 December 2003/ Returned for modification 12 January 2004/ Accepted 2 March 2004

Helicobacter pylori induces motogenic and cytoskeletal responses in gastric epithelial cells. We demonstrate that these responses can be induced via independent signaling pathways that often occur in parallel. The cag pathogenicity island appears to be nonessential for induction of motility, whereas the elongation phenotype depends on translocation and phosphorylation of CagA.

* Corresponding author. Mailing address: Otto von Guericke University, Dept. of Medical Microbiology, Leipziger Str. 44, D-39120 Magdeburg, Germany. Phone: 49 0391-67 13329. Fax: 49 0391-67 190469. E-mail: Steffen.Backert{at}medizin.uni-magdeburg.de.

Editor: D. L. Burns

Infection and Immunity, June 2004, p. 3646-3649, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3646-3649.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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