IAI FigSearch
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Amin, M.
Right arrow Articles by Ellen, R. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Amin, M.
Right arrow Articles by Ellen, R. P.
Infection and Immunity, June 2004, p. 3650-3654, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3650-3654.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Induction of De Novo Subcortical Actin Filament Assembly by Treponema denticola Major Outer Sheath Protein

Mohsen Amin, Andy C. S. Ho, Jenny Y. Lin, Andre Paes Batista da Silva, Michael Glogauer, and Richard P. Ellen*

CIHR Group in Matrix Dynamics and Dental Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1G6

Received 12 December 2003/ Returned for modification 21 January 2004/ Accepted 13 February 2004

Treponema denticola and its major outer sheath protein (Msp) induce actin reorganization in fibroblasts. We adapted a barbed-end labeling/imaging assay to monitor Msp-induced subcortical actin filament assembly in neutrophils and fibroblasts. Msp, at an actin-reorganizing concentration, inhibited migration of these dissimilar cell types, whose cytoskeletal functions in locomotion and phagocytosis are crucial for immunity and healing of peripheral infections.

* Corresponding author. Mailing address: University of Toronto, Faculty of Dentistry, 124 Edward St., Toronto, Canada M5G 1G6. Phone: 416-979-4917, ext. 4456. Fax: 416-979-4936. E-mail: richard.ellen{at}utoronto.ca.

Editor: J. B. Bliska

Infection and Immunity, June 2004, p. 3650-3654, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3650-3654.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. J. Virol. Eukaryot. Cell
Microbiol. Mol. Biol. Rev. Clin. Vaccine Immunol. All ASM Journals

Copyright © 2004 by the American Society for Microbiology. All rights reserved.