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Infection and Immunity, June 2004, p. 3650-3654, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3650-3654.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Induction of De Novo Subcortical Actin Filament Assembly by Treponema denticola Major Outer Sheath Protein

Mohsen Amin, Andy C. S. Ho, Jenny Y. Lin, Andre Paes Batista da Silva, Michael Glogauer, and Richard P. Ellen*

CIHR Group in Matrix Dynamics and Dental Research Institute, University of Toronto, Toronto, Ontario, Canada M5G 1G6

Received 12 December 2003/ Returned for modification 21 January 2004/ Accepted 13 February 2004

Treponema denticola and its major outer sheath protein (Msp) induce actin reorganization in fibroblasts. We adapted a barbed-end labeling/imaging assay to monitor Msp-induced subcortical actin filament assembly in neutrophils and fibroblasts. Msp, at an actin-reorganizing concentration, inhibited migration of these dissimilar cell types, whose cytoskeletal functions in locomotion and phagocytosis are crucial for immunity and healing of peripheral infections.

* Corresponding author. Mailing address: University of Toronto, Faculty of Dentistry, 124 Edward St., Toronto, Canada M5G 1G6. Phone: 416-979-4917, ext. 4456. Fax: 416-979-4936. E-mail: richard.ellen{at}utoronto.ca.

Editor: J. B. Bliska

Infection and Immunity, June 2004, p. 3650-3654, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3650-3654.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Puthengady Thomas, B., Sun, C. X., Bajenova, E., Ellen, R. P., Glogauer, M. (2006). Modulation of Human Neutrophil Functions In Vitro by Treponema denticola Major Outer Sheath Protein. Infect. Immun. 74: 1954-1957 [Abstract] [Full Text]  
  • Bian, X.-l., Wang, H.-t., Ning, Y., Lee, S. Y., Fenno, J. C. (2005). Mutagenesis of a Novel Gene in the prcA-prtP Protease Locus Affects Expression of Treponema denticola Membrane Complexes. Infect. Immun. 73: 1252-1255 [Abstract] [Full Text]  


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