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Infection and Immunity, June 2004, p. 3658-3663, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3658-3663.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Influence of Origin of Isolates, Especially Endocarditis Isolates, and Various Genes on Biofilm Formation by Enterococcus faecalis

Jamal A. Mohamed,1,2 Wenxiang Huang,1,2 Sreedhar R. Nallapareddy,1,2 Fang Teng,1,2 and Barbara E. Murray1,2,3*

Division of Infectious Diseases, Department of Internal Medicine,1 Center for the Study of Emerging and Reemerging Pathogens,2 Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas 770303

Received 10 September 2003/ Returned for modification 21 November 2003/ Accepted 19 January 2004

Endocarditis isolates of Enterococcus faecalis produced biofilm significantly more often than nonendocarditis isolates, and 39% of 79 versus 6% of 84 isolates produced strong biofilm (P < 0.0001). esp was not required, but its presence was associated with higher amounts of biofilm (P < 0.001). Mutants disrupted in dltA, efaA, ace, lsa, and six two-component regulatory systems were largely unaltered, while disruptions in epa, atn, gelE, and fsr resulted in fewer attached bacteria, as determined using phase-contrast microscopy, and less biofilm (P < 0.0001).

* Corresponding author. Mailing address: Center for the Study of Emerging and Reemerging Pathogens, Division of Infectious Diseases, JFB 1.728, University of Texas Medical School, 6431 Fannin St., Houston, TX 77030. Phone: (713) 500-6745. Fax: (713) 500-6766. E-mail: bem.asst{at}uth.tmc.edu.

Editor: F. C. Fang

Infection and Immunity, June 2004, p. 3658-3663, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3658-3663.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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