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Infection and Immunity, June 2004, p. 3664-3667, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3664-3667.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Biological Properties of Staphylococcal Enterotoxin-Like Toxin Type R

Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University, Ueda 3-18-8, Morioka, Iwate 020-8550,¹ Department of Microbiology and Immunology, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo 162-8666,² Department of Bacteriology, Hirosaki University School of Medicine, Hirosaki 036-8562,³ Department of Technical Support and Development, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba-shi 263-8555, Japan⁴

Received 4 December 2003/ Returned for modification 5 January 2004/ Accepted 6 March 2004

We investigated the biological properties of a novel staphylococcal enterotoxin-like putative toxin, staphylococcal enterotoxin-like toxin type R (SElR). Major histocompatibility complex class II molecules were required for T-cell stimulation by SElR. SElR stimulated T cells bearing receptors Vß 3, 11, 12, 13.2, and 14. These results suggested that SElR acts as a superantigen.

Editor: J. T. Barbieri

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