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Infection and Immunity, June 2004, p. 3668-3673, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3668-3673.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Role of Streptococcus pyogenes Two-Component Response Regulators in the Temporal Control of Mga and the Mga-Regulated Virulence Gene emm

Deborah A. Ribardo, Thomas J. Lambert, and Kevin S. McIver*

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9048

Received 11 November 2003/ Returned for modification 13 February 2004/ Accepted 27 February 2004

We examined the role of Streptococcus pyogenes two-component response regulators (SptR) in expression of Mga and the Mga-regulated gene emm. Both serotype M6 and serotype M1 mutants in 12 of the 13 identified sptR genes exhibited levels of emm transcripts and Mga protein comparable to those of the wild type during exponential and stationary phases of growth. Thus, temporal control of these virulence genes does not require Spt response regulators.

* Corresponding author. Mailing address: Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Hines Blvd., Dallas, TX 75235-9048. Phone: (214) 648-1255. Fax: (214) 648-5907. E-mail: kevin.mciver{at}utsouthwestern.edu.

Editor: V. J. DiRita

Infection and Immunity, June 2004, p. 3668-3673, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3668-3673.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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