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Infection and Immunity, June 2004, p. 3680-3683, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3680-3683.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Anaplasma phagocytophilum Infection Induces Protracted Neutrophil Degranulation

Kyoung-seong Choi,1 Dennis J. Grab,2 and J. Stephen Dumler1*

Division of Medical Microbiology, Department of Pathology,1 Division of Infectious Diseases, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland2

Received 3 March 2003/ Returned for modification 2 February 2004/ Accepted 4 March 2004

Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for >=18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

* Corresponding author. Mailing address: Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Ave., Ross 624, Baltimore, MD 21205. Phone: (410) 955-8654. Fax: (443) 287-3665. E-mail: sdumler{at}jhmi.edu.

Editor: W. A. Petri, Jr.

Infection and Immunity, June 2004, p. 3680-3683, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3680-3683.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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