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Infection and Immunity, June 2004, p. 3684-3687, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3684-3687.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Secretory Leucoprotease Inhibitor Impairs Toll-Like Receptor 2- and 4-Mediated Responses in Monocytic Cells

Catherine M. Greene,* Noel G. McElvaney, Shane J. O'Neill, and Clifford C. Taggart

Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland

Received 16 July 2003/ Returned for modification 22 October 2003/ Accepted 12 February 2004

Secretory leucoprotease inhibitor (SLPI) is an anti-inflammatory antiprotease which can inhibit lipopolysaccharide-induced NF-{kappa}B activation. We examined its ability to inhibit NF-{kappa}B activation induced by lipoteichoic acid and investigated the effects of oxidation or complex formation with neutrophil elastase on SLPI's anti-inflammatory properties in U937 myelomonocytic cells and macrophages.

* Corresponding author. Mailing address: Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. Phone: 353-1-8093800. Fax: 353-1-8093808. E-mail: cmgreene{at}rcsi.ie.

Editor: S. H. E. Kaufmann

Infection and Immunity, June 2004, p. 3684-3687, Vol. 72, No. 6
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.6.3684-3687.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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