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Antibodies Produced in Response to Cryptococcus neoformans Pulmonary Infection in Mice Have Characteristics of Nonprotective Antibodies

Departments of Medicine,² Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 10461¹

Received 27 January 2004/ Returned for modification 20 February 2004/ Accepted 16 March 2004

Murine cryptocococcal pulmonary infection elicited serum immunoglobulin M (IgM) and IgG to the capsular polysaccharide, but only IgG stained yeast cells in alveoli. Both isotypes produced punctuate immunofluorescence patterns on yeast cells like those of nonprotective antibodies. The difficulties involved in associating humoral immunity with protection in murine cryptocococcal infection could reflect nonprotective antibody responses.

Editor: T. R. Kozel

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