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Infection and Immunity, July 2004, p. 4271-4274, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4271-4274.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Antibodies Produced in Response to Cryptococcus neoformans Pulmonary Infection in Mice Have Characteristics of Nonprotective Antibodies

Oscar Zaragoza1 and Arturo Casadevall1,2*

Departments of Medicine,2 Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, 104611

Received 27 January 2004/ Returned for modification 20 February 2004/ Accepted 16 March 2004

Murine cryptocococcal pulmonary infection elicited serum immunoglobulin M (IgM) and IgG to the capsular polysaccharide, but only IgG stained yeast cells in alveoli. Both isotypes produced punctuate immunofluorescence patterns on yeast cells like those of nonprotective antibodies. The difficulties involved in associating humoral immunity with protection in murine cryptocococcal infection could reflect nonprotective antibody responses.

* Corresponding author. Mailing address: Departments of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. Phone: (718) 430-3665. Fax: (718) 430-8701. E-mail: casadeva{at}aecom.yu.edu.

Editor: T. R. Kozel

Infection and Immunity, July 2004, p. 4271-4274, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4271-4274.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • McFadden, D. C., Fries, B. C., Wang, F., Casadevall, A. (2007). Capsule Structural Heterogeneity and Antigenic Variation in Cryptococcus neoformans. Eukaryot Cell 6: 1464-1473 [Abstract] [Full Text]  
  • Zaragoza, O., Alvarez, M., Telzak, A., Rivera, J., Casadevall, A. (2007). The Relative Susceptibility of Mouse Strains to Pulmonary Cryptococcus neoformans Infection Is Associated with Pleiotropic Differences in the Immune Response. Infect. Immun. 75: 2729-2739 [Abstract] [Full Text]  
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  • Rivera, J., Zaragoza, O., Casadevall, A. (2005). Antibody-Mediated Protection against Cryptococcus neoformans Pulmonary Infection Is Dependent on B Cells. Infect. Immun. 73: 1141-1150 [Abstract] [Full Text]  


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