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Infection and Immunity, July 2004, p. 4275-4278, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4275-4278.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice

Gee W. Lau,1* Huimin Ran,1 Fansheng Kong,1 Daniel J. Hassett,2 and Dimitri Mavrodi3

Division of Pulmonary and Critical Care Medicine,1 Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0564,2 Department of Plant Pathology, Agricultural Research Service, Washington State University, Pullman, Washington 99164-64303

Received 4 February 2004/ Returned for modification 9 March 2004/ Accepted 12 March 2004

Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.

* Corresponding author. Mailing address: Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, MSB 6006, Cincinnati, OH 45267-0564. Phone: (513) 558-4410. Fax: (513) 558-4858. E-mail: gee.lau{at}uc.edu.

Editor: J. T. Barbieri

Infection and Immunity, July 2004, p. 4275-4278, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4275-4278.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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