This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hurd, E. A.
Right arrow Articles by Domino, S. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hurd, E. A.
Right arrow Articles by Domino, S. E.

 Previous Article  |  Next Article 

Infection and Immunity, July 2004, p. 4279-4281, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4279-4281.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Increased Susceptibility of Secretor Factor Gene Fut2-Null Mice to Experimental Vaginal Candidiasis

Elizabeth A. Hurd and Steven E. Domino*

<[ERROR]zaff;1[ERROR]>Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, Michigan

Received 18 December 2003/ Returned for modification 26 January 2004/ Accepted 2 April 2004

Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for {alpha}(1,2)fucosylated cervical glycans in mucosal defense. However, the lack of significant effect of competitive inhibition by exogenous neoglycoproteins in this study emphasizes the complexity of Candida-epithelial cell adhesion events.

* Corresponding author. Mailing address: Department of Obstetrics and Gynecology, 6428 Medical Science I, Box 0617, University of Michigan, Ann Arbor, MI 48109-0617. Phone: (734) 647-9562. Fax: (734) 936-8617. E-mail: sedomino{at}med.umich.edu.

Editor: T. R. Kozel

Infection and Immunity, July 2004, p. 4279-4281, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4279-4281.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fumagalli, M., Cagliani, R., Pozzoli, U., Riva, S., Comi, G. P., Menozzi, G., Bresolin, N., Sironi, M. (2009). Widespread balancing selection and pathogen-driven selection at blood group antigen genes. Genome Res 19: 199-212 [Abstract] [Full Text]  
  • Hurd, E. A., Holmen, J. M., Hansson, G. C., Domino, S. E. (2005). Gastrointestinal mucins of Fut2-null mice lack terminal fucosylation without affecting colonization by Candida albicans. Glycobiology 15: 1002-1007 [Abstract] [Full Text]  
  • Thomsson, K. A., Schulz, B. L., Packer, N. H., Karlsson, N. G. (2005). MUC5B glycosylation in human saliva reflects blood group and secretor status. Glycobiology 15: 791-804 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»