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Infection and Immunity, July 2004, p. 4279-4281, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4279-4281.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Increased Susceptibility of Secretor Factor Gene Fut2-Null Mice to Experimental Vaginal Candidiasis

Elizabeth A. Hurd and Steven E. Domino*

<[ERROR]zaff;1[ERROR]>Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, Michigan

Received 18 December 2003/ Returned for modification 26 January 2004/ Accepted 2 April 2004

Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for {alpha}(1,2)fucosylated cervical glycans in mucosal defense. However, the lack of significant effect of competitive inhibition by exogenous neoglycoproteins in this study emphasizes the complexity of Candida-epithelial cell adhesion events.

* Corresponding author. Mailing address: Department of Obstetrics and Gynecology, 6428 Medical Science I, Box 0617, University of Michigan, Ann Arbor, MI 48109-0617. Phone: (734) 647-9562. Fax: (734) 936-8617. E-mail: sedomino{at}med.umich.edu.

Editor: T. R. Kozel

Infection and Immunity, July 2004, p. 4279-4281, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4279-4281.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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