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Infection and Immunity, July 2004, p. 4282-4285, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4282-4285.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Multivariate Analysis of Cytokine Responses Identifies Distinctive Sensitivities to Lipopolysaccharide in Humans

David D. Duncan,* Lorrie Tiberio, and John H. Eldridge

Wyeth Research, Pearl River, New York 10965

Received 4 September 2003/ Returned for modification 29 January 2004/ Accepted 1 April 2004

We describe methods to identify high and low responders in a whole-blood assay of lipopolysaccharide-stimulated cytokine responses. Two multivariate measures of the cytokine responses both captured high and low responses for each of the four individual cytokines that were assayed.

* Corresponding author. Mailing address: 2005 Countrywood Ct., Encinitas, CA 92024. Phone: (760) 944-0310. E-mail: d_duncan{at}att.net.

Editor: F. C. Fang

Infection and Immunity, July 2004, p. 4282-4285, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4282-4285.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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