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Infection and Immunity, July 2004, p. 4286-4289, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4286-4289.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Chlamydia trachomatis Lacks an Adaptive Response to Changes in Carbon Source Availability

Tracy L. Nicholson,1,{dagger} Karen Chiu,1 and Richard S. Stephens1,2*

Program in Infectious Diseases, School of Public Health, University of California, Berkeley, Berkeley, California 94720,1 Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California 941432

Received 21 November 2003/ Returned for modification 4 February 2004/ Accepted 17 March 2004

Most bacteria coordinately regulate gene expression as an adaptive response to a variety of environmental changes. One key environmental cue is the carbon source necessary for central metabolism. We used microarray analysis to monitor the global transcriptional response of the obligate intracellular pathogen Chlamydia trachomatis to the presence of glycolytic and gluconeogenic carbon sources. In contrast to free-living bacteria, changing the carbon source from glucose to glutamate or {alpha}-ketoglutarate had little effect on the global gene transcription of C. trachomatis.

* Corresponding author. Mailing address: Program in Infectious Diseases, School of Public Health, University of California, Berkeley, 140 Earl Warren Hall, Berkeley, CA 94720-7360. Phone: (510) 643-9900. Fax: (510) 643-1537. E-mail: RSS{at}Berkeley.edu.

Editor: A. D. O'Brien

{dagger} Present address: Respiratory Diseases of Livestock Research Unit, National Animal Disease Center, USDA Agricultural Research Service, Ames, IA 50010.

Infection and Immunity, July 2004, p. 4286-4289, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4286-4289.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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