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Infection and Immunity, July 2004, p. 4290-4292, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4290-4292.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Multiserotype Protection of Mice against Pneumococcal Colonization of the Nasopharynx and Middle Ear by Killed Nonencapsulated Cells Given Intranasally with a Nontoxic Adjuvant

Richard Malley,1* Sarah C. Morse,1 Luciana C. C. Leite,2 Ana Paula Mattos Areas,2 Paulo Lee Ho,2 Flavia S. Kubrusly,2 Igor C. Almeida,3 and Porter Anderson4

Division of Infectious Diseases, Department of Medicine, Children's Hospital, Boston, Massachusetts,1 Instituto Butantan,2 Department of Parasitology, Institute of Biomedical Sciences and Institute of Chemistry, University of São Paulo, São Paulo, Brazil,3 Division of Immunology and Infectious Diseases, Department of Pediatrics, University of Rochester, Rochester, New York4

Received 1 December 2003/ Returned for modification 5 January 2004/ Accepted 31 March 2004

Intranasal challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites. Of four nontoxic adjuvants tested, the cholera toxin B subunit was most effective and least nonspecifically protective.

* Corresponding author. Mailing address: Division of Infectious Diseases, Children's Hospital, 300 Longwood Ave., Boston, MA 02115. Phone: 617-355-7456. Fax: 617-730-0254. E-mail: richard.malley{at}childrens.harvard.edu.

Editor: J. N. Weiser

Infection and Immunity, July 2004, p. 4290-4292, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4290-4292.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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