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Infection and Immunity, July 2004, p. 4297-4301, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4297-4301.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Oral Immunization with an rfaH Mutant Elicits Protection against Salmonellosis in Mice

Gábor Nagy,1 Ulrich Dobrindt,2 Jörg Hacker,2 and Levente Emödy1*

Institute of Medical Microbiology and Immunology, University of Pécs, 7624 Pécs, Hungary,1 Institut für Molekulare Infektionsbiologie, Universität Würzburg, 97070 Würzburg, Germany2

Received 4 October 2003/ Returned for modification 1 December 2003/ Accepted 23 March 2004

Loss of the transcriptional antiterminator RfaH results in virulence attenuation (>104-fold increase in 50% lethal dose) of the archetypal Salmonella enterica serovar Typhimurium strain SL1344 by both orogastric and intraperitoneal routes of infection in BALB/c mice. Oral immunization with the mutant efficiently protects mice against a subsequent oral infection with the wild-type strain. Interestingly, in vitro immunoreactivity is not confined to strain SL1344; rather, it is directed also towards other serovars of S. enterica and even Salmonella bongori strains.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Immunology, University of Pécs, Szigeti út 12, 7624 Pécs, Hungary. Phone: 36 72 536252. Fax: 36 72 536253. E-mail: levente.emody{at}aok.pte.hu.

Editor: A. D. O'Brien

Infection and Immunity, July 2004, p. 4297-4301, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4297-4301.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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