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Infection and Immunity, July 2004, p. 4322-4326, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4322-4326.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Highly Purified Lipoteichoic Acid from Staphylococcus aureus Induces Procoagulant Activity and Tissue Factor Expression in Human Monocytes but Is a Weak Inducer in Whole Blood: Comparison with Peptidoglycan

Eva Mattsson,1* Thomas Hartung,2 Siegfried Morath,2 and Arne Egesten3

Department of Cell and Molecular Biology, Lund University, Lund,1 Department of Medical Microbiology, Lund University, Malmö University Hospital, Malmö, Sweden,3 Biochemical Pharmacology, University of Konstanz, Konstanz, Germany2

Received 8 February 2004/ Returned for modification 15 March 2004/ Accepted 5 April 2004

Lipoteichoic acid from Staphylococcus aureus was a potent inducer of procoagulant activity in isolated mononuclear cells but not in whole blood. In contrast, staphylococcal peptidoglycan showed equal levels of potency in isolated mononuclear cells and whole blood, suggesting that peptidoglycan is an important inducer of procoagulant activity in severe sepsis involving gram-positive bacteria.

* Corresponding author. Mailing address: Department of Clinical Microbiology, University Hospital Utrecht, Heidelberglaan 100, P.O. Box 85.500, 3508 GA Utrecht, Holland. Phone: 31-30-2507627. Fax: 31-30-541770. E-mail: eva.mattsson{at}wanadoo.nl.

Editor: A. D. O'Brien

Infection and Immunity, July 2004, p. 4322-4326, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4322-4326.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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