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Infection and Immunity, July 2004, p. 4327-4329, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4327-4329.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Docosahexaenoic Acid and Eicosapentaenoic Acid Antagonize the Proinflammatory Interactions of Pneumolysin with Human Neutrophils

Riana Cockeran,1* Annette J. Theron,1 Charles Feldman,2 Timothy J. Mitchell,3 and Ronald Anderson1

Medical Research Council for Inflammation and Immunity, Department of Immunology, Faculty of Health Sciences, University of Pretoria, and Tshwane Academic Division of the National Health Laboratory Services, Pretoria,1 Division of Pulmonology, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa,2 Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom3

Received 10 November 2003/ Returned for modification 17 February 2004/ Accepted 10 March 2004

Pneumolysin (4.18 ng/ml)-mediated influx of Ca2+ and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 µg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.

* Corresponding author. Mailing address: Department of Immunology, P.O. Box 2034, Pretoria 0001, South Africa. Phone: 27-12-319 2425. Fax: 27-12-323 0732. E-mail: rcockera{at}medic.up.ac.za.

Editor: D. L. Burns

Infection and Immunity, July 2004, p. 4327-4329, Vol. 72, No. 7
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.7.4327-4329.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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