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Infection and Immunity, August 2004, p. 4864-4867, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4864-4867.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The luxS Gene Is Not Required for Borrelia burgdorferi Tick Colonization, Transmission to a Mammalian Host, or Induction of Disease

Jon S. Blevins,1 Andrew T. Revel,1 Melissa J. Caimano,2 Xiaofeng F. Yang,1 James A. Richardson,3 Kayla E. Hagman,1 and Michael V. Norgard1*

Departments of Microbiology,1 Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390,3 Department of Pathology and Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 060302

Received 5 February 2004/ Returned for modification 10 March 2004/ Accepted 7 April 2004

luxS mutants of Borrelia burgdorferi strain 297 naturally colonized their arthropod (Ixodes scapularis) vector, were maintained in ticks throughout the molting process (larvae to nymphs), were tick transmitted to uninfected mice, and elicited histopathology in mice indistinguishable from that induced by wild-type B. burgdorferi.

* Corresponding author. Mailing address: Department of Microbiology, U.T. Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75390-9048. Phone: (214) 648-5900. Fax: (214) 648-5905. E-mail: michael.norgard{at}utsouthwestern.edu.

Editor: D. L. Burns

Infection and Immunity, August 2004, p. 4864-4867, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4864-4867.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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