This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Clemons, K. V. Articles by Stevens, D. A. Search for Related Content PubMed PubMed Citation Articles by Clemons, K. V. Articles by Stevens, D. A.

 Previous Article  |  Next Article 

Infection and Immunity, August 2004, p. 4878-4880, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4878-4880.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Genetic Susceptibility of Mice to Candida albicans Vaginitis Correlates with Host Estrogen Sensitivity

Karl V. Clemons,^1,2,3* Jimmy L. Spearow,^4, Rachana Parmar,¹ Marife Espiritu,¹ and David A. Stevens^1,2,3

California Institute for Medical Research,¹ Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, California 95128,² Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California 94305,³ Section on Neurobiology, Physiology and Behavior, University of California, Davis, California 95616⁴

Received 16 January 2004/ Returned for modification 1 March 2004/ Accepted 3 May 2004

We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 CD10 CD10 x CD3F1 > CD10 x B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 x B6F1 animals and dominant in CD10 x CD3F1 animals.

Editor: T. R. Kozel

Present address: Department of Environmental Toxicology, University of California, Davis, CA 95616.

This article has been cited by other articles:

• Cassone, A., De Bernardis, F., Santoni, G. (2007). Anticandidal Immunity and Vaginitis: Novel Opportunities for Immune Intervention. Infect. Immun. 75: 4675-4686 [Full Text]  
• Clemons, K. V., Gonzalez, G. M., Singh, G., Imai, J., Espiritu, M., Parmar, R., Stevens, D. A. (2006). Development of an orogastrointestinal mucosal model of candidiasis with dissemination to visceral organs.. Antimicrob. Agents Chemother. 50: 2650-2657 [Abstract] [Full Text]