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Infection and Immunity, August 2004, p. 4881-4883, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4881-4883.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Mycoplasma penetrans Is Capable of Activating V{gamma}9/V{delta}2 T Cells While Other Human Pathogenic Mycoplasmas Fail To Do So

Matthias Eberl,1* Martin Hintz,1 Zandraa Jamba,1 Ewald Beck,1 Hassan Jomaa,1 and Gunna Christiansen2

Biochemisches Institut, Justus-Liebig-Universität Giessen, Giessen, Germany,1 Institut for Medicinsk Mikrobiologi og Immunologi, Aarhus Universitet, Århus, Denmark2

Received 20 February 2004/ Returned for modification 5 April 2004/ Accepted 6 May 2004

While most mycoplasma species appear to have evolutionarily lost the ability to synthesize isoprenoid precursors, Mycoplasma penetrans has retained the nonmevalonate pathway that proceeds via the immunogenic intermediate (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Consequently, this pathogen is capable of stimulating human V{gamma}9/V{delta}2 T cells.

* Corresponding author. Mailing address: Biochemisches Institut, Infektiologie, Justus-Liebig-Universität Giessen, Friedrichstrasse 24, 35392 Giessen, Germany. Phone: (49) 641 99 47442. Fax: (49) 641 99 47529. E-mail: matthias.eberl{at}biochemie.med.uni-giessen.de.

Editor: J. D. Clements

Infection and Immunity, August 2004, p. 4881-4883, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4881-4883.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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