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Infection and Immunity, August 2004, p. 4884-4887, Vol. 72, No. 8
0019-9567/04/$08.00+0 DOI: 10.1128/IAI.72.8.4884-4887.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
Research Center,1 Technology Development, Chiron Vaccines, 53100 Siena, Italy2
Received 20 February 2004/ Returned for modification 1 April 2004/ Accepted 24 April 2004
N19, a string of human universal CD4 T-cell epitopes from various pathogen-derived antigens, was shown to exert a stronger carrier effect than CRM197 for the induction of anti-group C Neisseria meningitidis capsular polysaccharide (MenC), after immunization of mice with various dosages of N19-MenC or CRM-MenC conjugate vaccines. After two immunizations, the N19-based construct induced anti-MenC antibody and protective bactericidal antibody titers higher than those induced by three doses of the CRM-MenC conjugate and required lower amounts of conjugate. N19-based conjugates are superior to CRM-based conjugates to induce protective immune responses to MenC conjugates.
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