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Infection and Immunity, August 2004, p. 4888-4890, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4888-4890.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Biofilm Formation In Vitro and Virulence In Vivo of Mutants of Klebsiella pneumoniae

Heather F. Lavender, Jennifer R. Jagnow, and Steven Clegg*

Department of Microbiology, College of Medicine, University of Iowa, Iowa City, Iowa 52242

Received 26 November 2003/ Returned for modification 24 February 2004/ Accepted 21 April 2004

One of the early stages of Klebsiella pneumoniae airway infections may involve biofilm formation. Bacterial biofilm formation is frequently investigated using in vitro techniques that facilitate identification and analysis of individual genes. We investigated the correlation between K. pneumoniae biofilm formation in vitro and ability to cause infection in vivo following construction of a bank of mini-Tn5 mutants.

* Corresponding author. Mailing address: Department of Microbiology, College of Medicine, University of Iowa, Iowa City, IA 52242. Phone: (319) 335-7778. Fax: (319) 335-9006. E-mail: Steven-clegg{at}uiowa.edu.

Editor: V. J. DiRita

Infection and Immunity, August 2004, p. 4888-4890, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4888-4890.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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