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Infection and Immunity, August 2004, p. 4891-4894, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4891-4894.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Inhibition of Nitric Oxide Synthase Exacerbates Group B Streptococcus Sepsis and Arthritis in Mice

Manuela Puliti,1 Christina von Hunolstein,2 Francesco Bistoni,1 Graziella Orefici,2 and Luciana Tissi1*

Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia,1 Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Rome, Italy2

Received 19 December 2003/ Returned for modification 15 March 2004/ Accepted 6 May 2004

The role of nitric oxide in group B Streptococcus (GBS) infection was evaluated by inhibiting its production with aminoguanidine (AG). AG-treated mice displayed higher mortality rates and more frequent and severe arthritis than controls. Worsening of arthritis correlated with a higher number of GBS cells in the joints and local interleukin-1ß production.

* Corresponding author. Mailing address: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy. Phone: 39 075 585 7409. Fax: 39 075 585 7400. E-mail: tissi{at}unipg.it.

Editor: V. J. DiRita

Infection and Immunity, August 2004, p. 4891-4894, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4891-4894.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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