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Infection and Immunity, August 2004, p. 4905-4910, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4905-4910.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Role of Flagellum and Motility in Pathogenesis of Vibrio vulnificus

Jong-Ho Lee,1 Jong Bok Rho,2 Kyung-Je Park,2 Chang Beom Kim,2 Yang-Soo Han,2 Sang Ho Choi,3 Kyu-Ho Lee,2 and Soon-Jung Park1*

Department of Parasitology and Institute of Tropical Medicine, BK21 Project for Medical Science, Yonsei University, Seoul 120-752,1 Department of Environmental Science, Hankuk University of Foreign Studies, Yongin 449-791,2 Department of Food Science and Technology, School of Agricultural Biotechnology and Center for Biomaterials, Seoul National University, Seoul 151-742, Korea3

Received 12 November 2003/ Returned for modification 18 February 2004/ Accepted 27 April 2004

To assess the role of the flagellum which was detected by immunoscreening of surface proteins of Vibrio vulnificus, an flgE-deleted mutant was constructed and tested for its pathogenicity. The ability of this nonmotile mutant to adhere to INT-407 cells and its role in biofilm were decreased, as was its lethality to mice.

* Corresponding author. Mailing address: Department of Parasitology, Yonsei University School of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 152-750, Korea. Phone: 82-2-361-5295. Fax: 82-2-363-8676. E-mail: sjpark615{at}yumc.yonsei.ac.kr.

Editor: V. J. DiRita

Infection and Immunity, August 2004, p. 4905-4910, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4905-4910.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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