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Infection and Immunity, August 2004, p. 4918-4923, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4918-4923.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Involvement of the Chemokine RANTES (CCL5) in Resistance to Experimental Infection with Leishmania major

Helton da Costa Santiago,1 Carolina Ferreira Oliveira,1 Luciana Santiago,1 Fernanda Oliveira Ferraz,1 Daniele da Glória de Souza,1 Luiz Antônio Rodrigues De-Freitas,2 Luís Carlos Crocco Afonso,3 Mauro Martins Teixeira,1 Ricardo Tostes Gazzinelli,1,4 and Leda Quercia Vieira1*

Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais,1 Centro de Pesquisas René Rachou, FioCruz, Belo Horizonte MG,4 Centro de Pesquisas Gonçalo Muniz, FioCruz, Salvador, Bahia,2 Departamento de Ciências Biológicas and Núcleo de Pesquisa em Ciências Biológicas, Instituto de Ciências Biológicas e Exatas, Universidade Federal de Ouro Preto, Ouro Preto MG, Brazil3

Received 20 August 2003/ Returned for modification 17 December 2003/ Accepted 3 April 2004

The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.

* Corresponding author. Mailing address: Departamento de Bioquímica e Imunologia, ICB-Universidade Federal de Minas Gerais, CP 486, 30161-970, Belo Horizonte MG, Brazil. Phone: 55-31-34992656. Fax: 55-31-3499-2614. E-mail: lqvieira{at}icb.ufmg.br.

Editor: J. F. Urban, Jr.

Infection and Immunity, August 2004, p. 4918-4923, Vol. 72, No. 8
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.8.4918-4923.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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