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Infection and Immunity, September 2004, p. 5446-5451, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5446-5451.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Neuroendocrine Stress Hormone Norepinephrine Augments Escherichia coli O157:H7-Induced Enteritis and Adherence in a Bovine Ligated Ileal Loop Model of Infection

Isabella Vlisidou,1 Mark Lyte,2 Pauline M. van Diemen,1 Pippa Hawes,3 Paul Monaghan,3 Timothy S. Wallis,1 and Mark P. Stevens1*

Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire,1 Bioimaging Department, Institute for Animal Health, Pirbright Laboratory, Surrey, United Kingdom,3 Department of Surgery, Minneapolis Medical Research Foundation/Hennepin County Medical Center, Minneapolis, and Department of Biological Sciences, Minnesota State University—Mankato, Mankato, Minnesota2

Received 10 March 2004/ Returned for modification 28 April 2004/ Accepted 13 May 2004

The role of the neuroendocrine environment in the pathogenesis of enteric bacterial infections is increasingly being recognized. Here we report that norepinephrine augments Escherichia coli O157:H7-induced intestinal inflammatory and secretory responses as well as bacterial adherence to intestinal mucosa in a bovine ligated ileal loop model of infection. Norepinephrine modulation of enteritis and adherence was dependent on the ability of E. coli O157:H7 to form attaching and effacing lesions.

* Corresponding author. Mailing address: Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire, RG20 7NN, United Kingdom. Phone: 44 1635 578411. Fax: 44 1635 577243. E-mail: mark-p.stevens{at}bbsrc.ac.uk.

Editor: A. D. O'Brien

Infection and Immunity, September 2004, p. 5446-5451, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5446-5451.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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