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Infection and Immunity, September 2004, p. 5460-5463, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5460-5463.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The Capsule of Bacillus anthracis Behaves as a Thymus-Independent Type 2 Antigen

Taia T. Wang and Alexander H. Lucas*

Children's Hospital Oakland Research Institute, Oakland, California

Received 22 April 2004/ Returned for modification 1 June 2004/ Accepted 14 June 2004

Bacillus anthracis elaborates a homopolymeric capsule composed of {gamma}-D-glutamic acid residues. Mice were immunized with formalin-fixed encapsulated B. anthracis bacilli, and the serum antibody response to a {gamma}-D-glutamyl capsular epitope was measured. Antiglutamyl antibodies were elicited in athymic BALB/c Nu/Nu, BALB/c Nu/+, and CBA/J mice but not in CBA/N xid mice. These response patterns define the capsule of B. anthracis as a thymus-independent type 2 antigen.

* Corresponding author. Mailing address: Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609. Phone: (510) 450-7635. Fax: (510) 601-3911. E-mail: alucas{at}chori.org.

Editor: A. D. O'Brien

Infection and Immunity, September 2004, p. 5460-5463, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5460-5463.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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