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Infection and Immunity, September 2004, p. 5483-5486, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5483-5486.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The AraC Family Transcriptional Regulator Rv1931c Plays a Role in the Virulence of Mycobacterium tuberculosis

Cristiane C. Frota, K. G. Papavinasasundaram, Elaine O. Davis,^* and M. Joseph Colston

Division of Mycobacterial Research, National Institute for Medical Research, London, United Kingdom

Received 9 March 2004/ Returned for modification 6 May 2004/ Accepted 8 June 2004

A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important for virulence of M. tuberculosis.

In memory of the late Jo Colston and Peter Jenner, for their support and many helpful discussions.

Editor: S. H. E. Kaufmann

Present address: Division of Medical Microbiology, Departamento de Patologia, Federal University of Ceara, Fortaleza-Ceara 60441-750, Brazil.

Present address: Department of Medicine, UBC Division of Infectious Diseases, Vancouver, BC V5Z 3J5, Canada.

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