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Infection and Immunity, September 2004, p. 5487-5492, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5487-5492.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Both Expansion of Regulatory GR1+ CD11b+ Myeloid Cells and Anergy of T Lymphocytes Participate in Hyporesponsiveness of the Lung-Associated Immune System during Acute Toxoplasmosis

Mathieu-Benoît Voisin,1 Dominique Buzoni-Gatel,2 Daniel Bout,1 and Florence Velge-Roussel1*

UMR Université-INRA d'Immunologie Parasitaire et Vaccinologie, UFR des Sciences Pharmaceutiques, Tours,1 Unité Réponse Précoce aux Parasites et Immunopathologie, Institut Pasteur/Institut National de la Recherche Agronomique, Paris, France2

Received 13 March 2004/ Returned for modification 18 April 2004/ Accepted 15 June 2004

Oral infection with Toxoplasma gondii leads to transient systemic hyporesponsiveness. In this report, we characterized the presence in the lungs of GR1+ CD11b+ myeloid cells that have potent nitric oxide-dependent immunoregulatory properties. We also demonstrated the interleukin 2-reversible anergy of both pulmonary CD8+ and CD4+ activated T lymphocytes with infection.

* Corresponding author. Mailing address: UMR Université-INRA 483 Immunologie Parasitaire et Vaccinologie, UFR des Sciences Pharmaceutiques, 31 avenue Monge, 37200 Tours, France. Phone: 33 247 366 146. Fax: 33 247 366 095. E-mail: florence.velge-roussel{at}univ-tours.fr.

Editor: W. A. Petri, Jr.

Infection and Immunity, September 2004, p. 5487-5492, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5487-5492.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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