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Infection and Immunity, September 2004, p. 5502-5505, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5502-5505.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Protection of Black-Tailed Prairie Dogs (Cynomys ludovicianus) against Plague after Voluntary Consumption of Baits Containing Recombinant Raccoon Poxvirus Vaccine

Jordan S. Mencher,1,2 Susan R. Smith,2 Tim D. Powell,3 Dan T. Stinchcomb,3 Jorge E. Osorio,3,{dagger} and Tonie E. Rocke2*

Wildlife Science Group, University of Washington, Seattle, Washington,1 U.S. Geological Survey, National Wildlife Health Center, Madison, Wisconsin,2 Heska Corporation, Ft. Collins, Colorado3

Received 4 December 2003/ Returned for modification 13 January 2004/ Accepted 28 May 2004

Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis and significant reservoirs of plague for humans in the western United States. A recombinant raccoon poxvirus, expressing the F1 antigen of Y. pestis, was incorporated into a palatable bait and offered to 18 black-tailed prairie dogs (Cynomys ludovicianus) for voluntary consumption; 18 negative control animals received placebo baits. Antibody titers against Y. pestis F1 antigen increased significantly (P < 0.01) in vaccinees, and their survival was significantly higher upon challenge with Y. pestis than that of negative controls (P < 0.01).

* Corresponding author. Mailing address: U.S. Geological Survey, National Wildlife Health Center, 6006 Schroeder Rd., Madison, WI 53711. Phone: (608) 270-2451. Fax: (608) 270-2415. E-mail: Tonie_Rocke{at}usgs.gov.

Editor: J. B. Bliska

{dagger} Present address: Inviragen, Mt. Horeb, WI 53572.

Infection and Immunity, September 2004, p. 5502-5505, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5502-5505.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rocke, T. E., Smith, S. R., Stinchcomb, D. T., Osorio, J. E. (2008). IMMUNIZATION OF BLACK-TAILED PRAIRIE DOG AGAINST PLAGUE THROUGH CONSUMPTION OF VACCINE-LADEN BAITS. J Wildl Dis 44: 930-937 [Abstract] [Full Text]  
  • Rocke, T. E., Smith, S., Marinari, P., Kreeger, J., Enama, J. T., Powell, B. S. (2008). VACCINATION WITH F1-V FUSION PROTEIN PROTECTS BLACK-FOOTED FERRETS (MUSTELA NIGRIPES) AGAINST PLAGUE UPON ORAL CHALLENGE WITH YERSINIA PESTIS. J Wildl Dis 44: 1-7 [Abstract] [Full Text]  
  • Webb, C. T., Brooks, C. P., Gage, K. L., Antolin, M. F. (2006). Classic flea-borne transmission does not drive plague epizootics in prairie dogs. Proc. Natl. Acad. Sci. USA 103: 6236-6241 [Abstract] [Full Text]  


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