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Infection and Immunity, September 2004, p. 5511-5514, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5511-5514.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Differential Monocyte Activation Underlies Strain-Specific Mycobacterium tuberculosis Pathogenesis

Claudia Manca,1 Michael B. Reed,2 Sherry Freeman,1 Barun Mathema,3 Barry Kreiswirth,3 Clifton E. Barry III,2 and Gilla Kaplan1*

Laboratory of Mycobacterial Immunity and Pathogenesis,1 Tuberculosis Center, Public Health Research Institute, International Center for Public Health, Newark, New Jersey,3 Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland2

Received 11 February 2004/ Returned for modification 29 March 2004/ Accepted 11 June 2004

In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced interleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.

* Corresponding author. Mailing address: Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, International Center for Public Health, 225 Warren St., Newark, NJ 07103-3535. Phone: (973) 854-3220. Fax: (973) 854-3222. E-mail: kaplan{at}phri.org.

Editor: S. H. E. Kaufmann

Infection and Immunity, September 2004, p. 5511-5514, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5511-5514.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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