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Differential Monocyte Activation Underlies Strain-Specific Mycobacterium tuberculosis Pathogenesis

Laboratory of Mycobacterial Immunity and Pathogenesis,¹ Tuberculosis Center, Public Health Research Institute, International Center for Public Health, Newark, New Jersey,³ Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland²

Received 11 February 2004/ Returned for modification 29 March 2004/ Accepted 11 June 2004

In vitro infection of monocytes with Mycobacterium tuberculosis HN878 and related W/Beijing isolates preferentially induced interleukin-4 (IL-4) and IL-13, which characterize Th2 polarized immunity. In contrast, CDC1551 induced more IL-12 and other molecules associated with phagocyte activation and Th1 protective immunity. The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection.

Editor: S. H. E. Kaufmann

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