Infection and Immunity, September 2004, p. 5515-5521, Vol. 72, No. 9
0019-9567/04/$08.00+0 DOI: 10.1128/IAI.72.9.5515-5521.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
The P Domain of the P0 Protein of Plasmodium falciparum Protects against Challenge with Malaria Parasites
K. Rajeshwari, Kalpesh Patel, Savithri Nambeesan, Monika Mehta, Alfica Sehgal,
Tirtha Chakraborty,
and Shobhona Sharma*
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India
Received 26 February 2004/
Returned for modification 9 April 2004/
Accepted 9 May 2004
Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum. Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.
* Corresponding author. Mailing address: Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd., Mumbai 400 005, India. Phone: 91-22-2280-4545, ext. 2570. Fax: 91-22-2280-4610. E-mail: sharma{at}tifr.res.in.
Editor: W. A. Petri, Jr.
Present address: Section of Infectious Diseases/Internal Medicine, School of Medicine, Yale University, New Haven, Conn.
Infection and Immunity, September 2004, p. 5515-5521, Vol. 72, No. 9
0019-9567/04/$08.00+0 DOI: 10.1128/IAI.72.9.5515-5521.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.
Copyright © 2004 by the American Society for Microbiology. All rights reserved.