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Infection and Immunity, September 2004, p. 5515-5521, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5515-5521.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

The P Domain of the P0 Protein of Plasmodium falciparum Protects against Challenge with Malaria Parasites

K. Rajeshwari, Kalpesh Patel, Savithri Nambeesan, Monika Mehta, Alfica Sehgal,{dagger} Tirtha Chakraborty,{dagger} and Shobhona Sharma*

Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, India

Received 26 February 2004/ Returned for modification 9 April 2004/ Accepted 9 May 2004

Monoclonal antibodies (MAbs) specific for the P domain of the Plasmodium falciparum P0 phosphoriboprotein (PfP0) blocked the invasion of RBCs by P. falciparum. Vaccination with this P-domain peptide protected mice upon malaria parasite challenge. The absolute specificity of the MAbs and the PfP0 P peptide makes them potential protective malaria reagents.

* Corresponding author. Mailing address: Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd., Mumbai 400 005, India. Phone: 91-22-2280-4545, ext. 2570. Fax: 91-22-2280-4610. E-mail: sharma{at}tifr.res.in.

Editor: W. A. Petri, Jr.

{dagger} Present address: Section of Infectious Diseases/Internal Medicine, School of Medicine, Yale University, New Haven, Conn.

Infection and Immunity, September 2004, p. 5515-5521, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5515-5521.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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