This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ASM journals
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kariuki, T. M.
Right arrow Articles by Coulson, P. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kariuki, T. M.
Right arrow Articles by Coulson, P. S.

 Previous Article  |  Next Article 

Infection and Immunity, September 2004, p. 5526-5529, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5526-5529.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Parameters of the Attenuated Schistosome Vaccine Evaluated in the Olive Baboon

Thomas M. Kariuki,1 Idle O. Farah,1 Dorcas S. Yole,1 Jason M. Mwenda,1 Govert J. Van Dam,2 André M. Deelder,2 R. Alan Wilson,3 and Patricia S. Coulson3*

Institute of Primate Research, Karen, Nairobi, Kenya,1 Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands,2 Department of Biology, University of York, York, United Kingdom3

Received 15 August 2003/ Returned for modification 20 December 2003/ Accepted 13 May 2004

Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response.

* Corresponding author. Mailing address: Department of Biology (Area 5), P.O. Box 373, University of York, York YO10 5YW, United Kingdom. Phone: (44) (0)1904 328599. Fax: (44) (0)1904 328599. E-mail: psc3{at}york.ac.uk.

Editor: J. F. Urban, Jr.

Infection and Immunity, September 2004, p. 5526-5529, Vol. 72, No. 9
0019-9567/04/$08.00+0     DOI: 10.1128/IAI.72.9.5526-5529.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kariuki, T. M., Van Dam, G. J., Deelder, A. M., Farah, I. O., Yole, D. S., Wilson, R. A., Coulson, P. S. (2006). Previous or Ongoing Schistosome Infections Do Not Compromise the Efficacy of the Attenuated Cercaria Vaccine. Infect. Immun. 74: 3979-3986 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»